Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process.High CXCR4 SPECIAL SET tumour expression is associated with poor prognosis of lung, brain, CNS, blood and breast cancers.We
Here we describe two term male infants diagnosed with X-linked CGD who present, in addition to frequent infection, with a unique papulopustular skin rash.CGD is caused by a number of genetic defects that impair phagocyte function.This disease results in recurrent infections and granuloma formation.Rarely do patients develop cutaneous symptoms, unle
Janus kinase 2 (JAK2) plays a critical role in myoblast proliferation and fat deposition in animals.Our previous RNA-Seq analyses identified a close association between the JAK2 Socks gene and muscle development.To date, research delving into the relationship between the JAK2 gene and growth traits has been sparse.In this study, we sought to invest